Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil generic ingredients Sudden blurry vision with plaquenil Hydroxychloroquine high dose Plaquenil anxiety side effect Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease. Mechanism of action of Chloroquine It interferes with the metabolism and hemoglobin utilization by the parasites by binding to and inhibiting the DNA and RNA polymerase. It also concentrates within the parasite vesicles and interferes with the acid-base balance of the parasite inhibiting the growth of the parasite. The sulfate and phosphate salts of chloroquine have both been commercialised as antimalarial drugs. Hydroxychloroquine has also been used as an antimalarial, but in addition is now broadly used in autoimmune diseases such as lupus and rheumatoid arthritis. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine phosphate mechanism of action Chloroquine - an overview ScienceDirect Topics, Chloroquine Nivaquine, Resochin Healing Is Divine. Buy aralen phosphateAralen dosage malaria prevention You should know that the 150mg base tablet is the same as the 250mg salt tablet and the 300mg base. tablet is the same as the 500mg salt tablet. It is just two different ways of describing the same thing. Chloroquine can be prescribed for either prevention or treatment of malaria. Medicines for the Prevention of Malaria While Traveling.. Of chloroquine and COVID-19 - ScienceDirect. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.