Chloroquine phosphate mechanism of action

Discussion in 'Aralen 150 Mg' started by BigMike, 26-Feb-2020.

  1. soulburner Well-Known Member

    Chloroquine phosphate mechanism of action


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease. Mechanism of action of Chloroquine It interferes with the metabolism and hemoglobin utilization by the parasites by binding to and inhibiting the DNA and RNA polymerase. It also concentrates within the parasite vesicles and interferes with the acid-base balance of the parasite inhibiting the growth of the parasite. The sulfate and phosphate salts of chloroquine have both been commercialised as antimalarial drugs. Hydroxychloroquine has also been used as an antimalarial, but in addition is now broadly used in autoimmune diseases such as lupus and rheumatoid arthritis.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine phosphate mechanism of action

    Chloroquine - an overview ScienceDirect Topics, Chloroquine Nivaquine, Resochin Healing Is Divine.

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  4. You should know that the 150mg base tablet is the same as the 250mg salt tablet and the 300mg base. tablet is the same as the 500mg salt tablet. It is just two different ways of describing the same thing. Chloroquine can be prescribed for either prevention or treatment of malaria.

    • Medicines for the Prevention of Malaria While Traveling..
    • Of chloroquine and COVID-19 - ScienceDirect.
    • Aralen Chloroquine Uses, Dosage, Side Effects..

    Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.

     
  5. chester65 New Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Overview Benralizumab for treating severe eosinophilic. Epithelial-stromal crosstalk and fibrosis in eosinophilic. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  6. Wait Guest

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Recommendations on Screening for Chloroquine and. Multimodal Imaging in Plaquenil Toxicity Hydroxychloroquine-Induced Retinal Toxicity - American.
     
  7. color Moderator

    Prednisone and plaquenil - This is a very popular and normal combination, I'd say that at least 75% of the lupus forum members have been on it! Plaquenil is an anti-malarial that slows the progression of the disease. Prednisone is a cortiocosteriod that manages inflammation. They have different jobs to do and don't interfere with each other. Hope Mom feels better soon.

    Prednisone and Plaquenil drug interactions - eHealthMe
     
  8. askon Guest

    Plaquenil Indications, Side Effects, Warnings - Oct 22, 2019 Tell your doctor if you sunburn easily while taking this drug. Low blood sugar has happened with Plaquenil hydroxychloroquine. Sometimes, this has been very bad and could be life-threatening. Talk with the doctor. Check your blood sugar as you have been told by your doctor. Talk with your doctor before you drink alcohol.

    Hydroxychloroquine Plaquenil