I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hydroxychloroquine fertility Plaquenil after gastric sleeve The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Backstory I was diagnosed with SLE 2 years ago, my rheumatologist prescribed plaquenil but this past month my diagnosis had changed to lupus nephritis stage 3. I was referred for a nephrologist who prescribed prednisone. I asked if I should take just the prednisone but he said I should stay on both. Prednisone is the steroid most commonly prescribed for lupus. It is usually given as tablets that come in 1, 5, 10, or 20 milligram mg doses. Pills may be taken as often as 4 times a day or as infrequently as once every other day. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Lupus plaquenil prednisone Lupus Medications and Treatments, Prednisone and Plaquenil prescribed at the same time? lupus Does magnesium affect plaquenilPlaquenil and excessive sweatingChloroquine phosphate fish medication dosagePlaquenil tablets hydroxychloroquine sulphateHydroxychloroquine and chloroquine retinopathy pdf Plaquenil hydroxychloroquine. Regular prednisone use causes the gland to stop making its own steroids. Prednisone Side Effects. Lupus patients get heart attacks at a younger age. Systemic Lupus Erythematosus Living With Lupus. Treating Lupus with Steroids Johns Hopkins Lupus Center. Plaquenil vs Prednisone Comparison -. Prednisone is the most commonly prescribed steroid for lupus. Prednisolone and methylprednisolone Medrol® are similar to prednisone. Some physicians prefer to prescribe these if you have liver problems. Most people take steroids in pill form. But, creams or gels applied to the skin are often used for cutaneous skin lupus. Risk factors include active lupus erythematosus, maintenance therapy using prednisone dosages of more than 20 mg daily, renal disease and hypertension Increased risk of premature rupture of the. I took prednisone for a week, & started taking 200mg plaquenil & 2400mg ibuprofen daily, & 50-150mg tramadol as needed for pain. In my experience, the prednisone helped to reduce the excruciating, debilitating joint pain by calming the inflammation, & plaqenil & ibuprofen keep it at bay.the most part.