Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Maculopathy from plaquenil Chloroquine and tlr signaling Votamin b deficiency feom plaquenil Hydroxychloroquine skin peeling Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms. Plaquenil Side Effects. Generic Name hydroxychloroquine. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil discolor yiur skin Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil Side Effects Common, Severe, Long Term - Chloroquine phosphate for ichReticulocytes chloroquine treatmentChloroquine phosphate ip 250 mgPros and cons of plaquenilPlaquenil help pleurisy Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Plaquenil & skin discoloration -. Common and Rare Side Effects for Plaquenil Oral. Skin discoloration - bluish is found among people who take Plaquenil, especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months, also take medication Imuran, and have Epilepsy. I was thinking maybe the cellcept but I think yap maybe the plaquenil too. Anyway, I show this to the doctor and he told me to use eucerin lotion. I told him that when I itch so bad I put alcohol maybe it is bacteria - but then he said do not put alcohol that can make worse to your skin. Nail discoloration is found among people who take Plaquenil, especially for people who are female, 50-59 old also take medication Enbrel, and have Bowen's disease. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly.