Ocular safety of hydroxychloroquine

Discussion in 'Canada Drug' started by uatara, 26-Feb-2020.

  1. megadoz Moderator

    Ocular safety of hydroxychloroquine


    Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE).

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    Macular Society Eye screening for patients taking hydroxychloroquine Hydroxychloroquine is a medication used to treat several conditions including rheumatoid arthritis, systemic lupus erythematosus, some skin conditions especially photosensitive ones and others that involve inflammation. It was previously used in the treatment and Hydroxychloroquine is still a safe and beneficial drug for use in rheumatic diseases. Retinal toxicity is unpredictable and can occur even at relatively low doses of hydroxychloroquine. There are new screening modalities for early detection of asymptomatic hydroxychloroquine ocular toxicity. Mar 17, 2019 Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.

    Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease.

    Ocular safety of hydroxychloroquine

    Plaquenil Risk Calculators, Hydroxychloroquine-related retinal toxicity Rheumatology.

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  6. Hydroxychloroquine balancing the need to maintain therapeutic levels with ocular safety an update. Abdulaziz N1, Shah AR2, McCune WJ1. Author information 1Division of Rheumatology, Department of Internal Medicine. 2Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.

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    Eye care specialists provide a valuable service when screening for Plaquenil retinal toxicity and advising the treating physician or rheumatologist with regards to the patient’s risk, safe dosing and appropriate screening procedures. Jan 18, 2019 Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight.

     
  7. igor456 User

    Acquiring HCQ is easier than CQ in some areas, so I have done some research to find some literature on HCQ. Getting the most from your lupus medications Lupus. Hydroxychloroquine - Plaquenil Alternative - LUPUS UK Hydroxychloroquine Plaquenil thread COVID19
     
  8. Yxaxa Guest

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Is Plaquenil a immunosuppressant drug ? Autoimmune Disorders Forums. Is Plaquenil a immunosuppressant drug ? Autoimmune.
     
  9. PAsa Guest

    Hydroxychloroquine sulfate Pill Images - What does. Hydroxychloroquine sulfate Images. What does Hydroxychloroquine sulfate look like? Note Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi ingredient medications may also be listed when applicable.

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  10. Colorado New Member

    Rheumatoid Arthritis Treatment Options Johns Hopkins. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.

    Hydroxychloroquine Plaquenil - medications for Rheumatoid Arthritis RA