Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine belong to what drug family Malaria plaquenil How common is hair loss with plaquenil If I am still having heartburn and stomach pain I add Pepcid AC and phyzme. I know for me part of the problem is all the meds I take in addition to Plaquenil, prednisone and a host of others. A more pleasant stomach calmer is anise, black licorice. Also I use only lactade free milk. I hope this helps some. Sorry to hear you are feeling so bad. I've been on Plaquenil for 4 1/2 years, 200mg with breakfast and 200mg with supper. I always make sure I take it with food and I've had no problem with it. It helped me so much, I hope I don't ever have to go off of it. Hope your tummy gets adjusted soon. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil stomach problems Plaquenil Side Effects Common, Severe, Long Term -, Lupus Board Index Plaquenil and stomach issues. Chloroquine phosphate in display tankCan you take plaquenil if you are allergic to sulfateCan plaquenil cause glaucomaHydroxychloroquine sulfa allergy I am on Plaquenil and it makes my stomach hurt. I take a lot of Tums and make sure I eat when I take my meds. Also, Plaquenil is hard on the eyes to some people so get them checked and tell your eye doctor you are on it and that you have RA. Good luck. I've been on plaquenil for about 14 years and have not had any problems with it. Plaquenil Arthritis Information. Plaquenil Oral Uses, Side Effects, Interactions.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks.