Please review the following URL and make sure that it is spelled correctly. Many people with rheumatoid arthritis, or RA, report having trouble thinking clearly, problems with memory, and difficulty concentrating. Plaquenil treatment Hydroxychloroquine otc Plaquenil generic drug Plaquenil sun rash Plaquenil hydroxychloroquine. "From my experience this should be taken off the market ASAP as it causes bad brain fog and bad headaches". The other immune drugs have scary side effects almost worth waiting for a flare and dealing with steroids then the side effects of the immune suppressants and plaquinel name brand and generic not. The brain fog immediately disappeared. In about a month, the pain and swelling came back, along with digestive problems, so the doctor cut the hydroxychloroquine back to 1 tablet a day, increased the prednisone and added a low dose of methotrexate. I am afraid of the methotrexate, but it does help with the pain and swelling. What is Plaquenil and what are its benefits for Sjögren’s patients? Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. With proper treatment and by taking preventative steps, a person with RA may be able to get the brain fog to lift. These symptoms, known as brain fog, are widespread in people with chronic inflammatory conditions, including RA, Sjogren’s syndrome, and multiple sclerosis. Does plaquenil effect the brain fog Lupus Fog – Changes in Memory and Thinking, RA, meds, and brain fog?" Rheumatoid Arthritis Community. Patient teaching for hydroxychloroquine Depression, anxiety, and brain fog could be Lupus symptoms -- or they could be from Remicade, I'm not familiar with it's side effects. Or they could be from something else entirely -- but they are not listed as side effects from Plaquenil. Plaquenil - Lupus. Ask the Expert Plaquenil and Sjögren’s. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. It does help with fatigue, but I don't think it helps with brain fog or other neuro symptoms. Plaquenil helps with joint pain but not muscle aches and pains. Actually one of the rare side effects is myopathy, which is muscle weakness.