Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Benlysta vs plaquenil Hydroxychloroquine and omeprazole Lupus can affect both the central nervous system the brain and spinal cord and the peripheral nervous system. Lupus may attack the nervous system via antibodies that bind to nerve cells or the blood vessels that feed them, or by interrupting the blood flow to nerves. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil nervous system Management of Neuropsychiatric Systemic Lupus., Hydroxychloroquine Plaquenil Another medication that can be taken with plaquenilHydroxychloroquine use during pregnancy Feb 19, 2020 Nervous system disorders Headache, dizziness, seizure, ataxia and extrapyramidal disorders such as dystonia, dyskinesia, and tremor have been reported with this class of drugs. Psychiatric disorders Affect/emotional lability, nervousness, irritability, nightmares, psychosis, suicidal behavior. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine - Wikipedia. Stopping Plaquenil - General Discussion - Life With Lupus. My husband was given plaquenil as a substitute for prednisone which was causing him severe weakness and weight loss. The plaquenil has caused ringing in his ears and he has experienced a strange twitching sensation inside his head which we are not sure if it is going with the plaquenil or the Immuran which he was also taking. Nervous system disorders Dizziness, headache, convulsions have been reported with this class of drugs. Eye disorders Retinopathy with changes in pigmentation and visual ﬁeld defects have been reported. In its early form, it appears reversible on discontinuation of hydroxychloroquine. If allowed to develop, Feb 19, 2020 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.