It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil hyperpigmentation histology Does plaquenil reduce rheumatoid arthritis Pigmentary changes in skin and mucous membranes, bleaching of hair, and alopecia are usually reversible when therapy is discontinued.-AGEP should be distinguished from psoriasis, although this drug may precipitate attacks of psoriasis; it may be associated with fever and hyperleukocytosis. Common 1% to 10% Rash, pruritus Aug 26, 2013 Plaquenil hydroxychloroquine is associated with a variety of rashes, and you should discuss with your doctor if a medication change would be the best treatment for your rash. Read more. It is licensed in the UK for the treatment of malaria. Hydroxychloroquine is particularly effective for systemic lupus erythematosus SLE and discoid lupus erythematosus DLE. By reducing inflammation, hydroxychloroquine can decrease pain, swelling and stiffness of joints, and improve or clear some rashes. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Plaquenil for skin rash Plaquenil hydroxychloroquine 200mg is it causing itchy., Plaquenil hydroxychloroquine 200mg is it causing itchy skin. Plaquenil effects on eyesChloroquine interaction Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine Skin Support. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. I had a skin rash from plaquenil hydroxychloroquine. I was put on a 21 day taper of prednisone. How long before the prednisone increases my odds of catching viruses? Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.