Chloroquine maculopathy

Discussion in 'Canadian Ed Drugstore' started by stanik, 25-Feb-2020.

  1. Moose New Member

    Chloroquine maculopathy


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. Risk Factors. There are risk factors which may increase the likelihood of an individual in developing symptoms of Plaquenil toxicity 1.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine maculopathy

    Expanded spectral domain-OCT findings in the early., Chloroquine retinopathy - Wikipedia

  2. Chloroquine stability in water
  3. Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.

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    Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. The Academy uses cookies to analyze performance and provide relevant personalized content to users of our website.

     
  4. Sweet Potato XenForo Moderator

    Quinine is a bitter compound that comes from the bark of the cinchona tree. If you are allergic to quinine can you take. Plaquenil Hydroxychloroquine Sulfate - Sanofi Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  5. nejronODP Guest

    What can Hydroxychloroquine Plaquenil do to my eyes? Jan 18, 2019 Hydroxychloroquine Plaquenil is a very useful drug to treat Rheumatoid Arthritis and Lupus but it can have some significant visual side effects unless properly dosed and monitored. What can Hydroxychloroquine Plaquenil do to my eyes?

    Plaquenil Side Effects on Your Eyes and Vision