Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and cold medicine Hydroxychloroquine sulfate tablets What does plaquenil deplete Can plaquenil cause dry mouth Factors that increase the risk of developing hydroxychloroquine associated retinal toxicity include daily dose, cumulative dose, renal or liver impairment, older age, and prior retinal disease. Specifically, a daily dose of 6.5mg/kg based on ideal body weight and a cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine are both considered risk factors for retinal toxicity. To calculate ideal body weight we need to know the gender and height of our subject, so I chose an average 5’4“ 64 inch or 1.625 meter tall woman women are more likely to be taking plaquenil. I discussed how ideal body weight is calculated in my previous post and I will not repeat it here. Most importantly, a 5’4” woman’s ideal weight will be 120.6 lbs 54.7 kg. Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity ideal body weight Hydroxychloroquine-Induced Retinal Toxicity - American., Changes to plaquenil risk calculations Hydroxychloroquine common thanChloroquine for infants The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Despite Plaquenil dosing recommendations, retinal toxicity.. Hydroxychloroquine toxicity - EyeWiki. Retinal toxicity associated with chronic exposure to.. Retinal toxicity than ideal body weight and allows estimations of risk that are independent of body habitusMaintaining daily use at 5.0mg/kg or less would keep both the cumulative risk and annual risk of retinal toxicity low, especially for the first 10 years of use.” • Melles RB, Marmor MF. Retinal damage from Plaquenil is extremely rare when doses do not exceed the maximum recommended which is about 3 mgs per lb/ 6.5 mgs per kilo of IDEAL body weight and when the patient has no liver or kidney problems. Since doses are cumulative the risk increases with time - 10 years is usually quoted. The Hydroxychloroquine Dosing Calculator calculates appropriate daily dose of hydroxychloroquine. If a patient is on a dose that exceeds 5 mg/kg/day of real body weight, the prescribing physician should be contacted to ensure that the dose can be adjusted and medical risks are managed. Ideal Body Weight and Adjusted Body Weight; Age.