What is the mechanism of action of chloroquine and primaquine

Discussion in 'Canadian Ed Drugstore' started by Citron, 25-Feb-2020.

  1. Meniam User

    What is the mechanism of action of chloroquine and primaquine

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The exact mechanism by which chloroquine inhibits hemozoin formation is not known, but chloroquine can bind heme and this binding may prevent the heme from being incorporated into the hemozin crystal. Parasite killing is therefore a result of the accumulation of metabolic wastes ie, heme associated with the digestion of hemoglobin. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. Mechanism of action Primaquine is lethal to P. vivax and P. ovale in the liver stage, and also to P. vivax in the blood stage through its ability to do oxidative damage to the cell. However, the exact mechanism of action is not fully understood.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    What is the mechanism of action of chloroquine and primaquine

    Primaquine – Malaria Site, On the molecular mechanism of chloroquine's antimalarial action PNAS

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  4. Mechanism of Action of Primaquine 7.5mg Primaquine is an 8-aminoquinoline antimalarial which eliminates the exoerythrocytic forms of malarial parasite P.vivax, P. falciparum by disrupting mitochondria and binding to DNA. By this action primaquine achieves radical cure of vivax malaria. It is also active against gametocytes of P.falciparum.

    • Primaquine 7.5mg Brands Prices, Side-effects, Uses, Dosage, Generic..
    • Primaquine - Wikipedia.

    Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive.

  5. denis_pl Moderator

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  7. GAIR Guest

    What Is Plaquenil? - American Academy of Ophthalmology Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision.

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