Please welcome our newest member, Angel Whisperer.274 Guest(s), 11 Registered Member(s) are currently online. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Common side effects of plaquenil Para que sirve el hydroxychloroquine 200 mg Most people say about 6 months. It works over time. Someone else told me that plaquenil could take up to a year to work. Others have told me that it only took a few months for them to feel the effects. Everyone is different. Typical dosage is 400 mg once per week, taken on the same day each week, starting 2 weeks before exposure to malaria. Continue using this medication during exposure and for 4 weeks after leaving. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. How long for plaquenil to work Ask the Expert Plaquenil and Sjögren’s, Plaquenil - Plaquenil deplete magnesiumPlaquenil 10 mgPlaquenil monitoring guidelinesChloroquine for lupus treatmentPlaquenil nausea vomiting Aug 14, 2017 According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Is This an Emergency? If you are experiencing serious medical symptoms, seek emergency treatment immediately. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil is sold in 200mg tablets. The recommended adult dosage for a person with lupus is 200 to 400 mg daily. It can be taken in two doses or at one time. Doses above 400 mg/day are not recommended. Re Plaquenil - How long till it works. It took me about 9 or 10 months. When I developed a severe flare, my rheumy started me on prednisone and plaquenil at the same time. This way while I tapered off the pred over 8 months, the plaquenil was building up in my system. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.