Chloroquine blood stage

Discussion in 'Canadian Pharcharmy Online' started by linad, 14-Mar-2020.

  1. kdx New Member

    Chloroquine blood stage

    “Presumptive treatment” without the benefit of laboratory confirmation should be reserved for extreme circumstances (strong clinical suspicion or severe disease in a setting where prompt laboratory diagnosis is not available). Once the diagnosis of malaria has been made, appropriate antimalarial treatment must be initiated immediately.

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    The blood stage antimalarial efficacy of primaquine 0.25 mg of base/kg of body weight/day over 14 days and chloroquine 25 mg of base/kg over 3 days were compared in 85 adult Thai men with acute Plasmodium vivax malaria. Most 75% had at least one malaria episode previously. Chloroquine phosphate is approved for suppressive treatment prophylaxis and for acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of Pf. Chloroquine is a blood-stage schizonticide, highly active against replicating forms of blood-stage drug- sensitive parasites. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. It increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, chloroquine inhibits the erythrocytic stage of development of plasmodia.

    The clinical status of the patient: Patients diagnosed with malaria are generally categorized as having either uncomplicated or severe malaria. Treatment should be guided by three main factors: infections, the urgent initiation of appropriate therapy is especially critical.

    Chloroquine blood stage

    Chloroquine Resistance in Plasmodium falciparum - microbewiki, Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine.

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  6. Blood stage treatment In most endemic countries, chloroquine remains the first-line treatment for P. vivax malaria. However, chloroquine resistance has been detected in many regions and in some cases has been replaced with artemisinin-based combination therapies ACTs.

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    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Oct 01, 2018 Chloroquine is not active against the gametocytes and the exoerythrocytic forms including the hypnozoite stage P. vivax and P. ovale of the Plasmodium parasites. In vitro studies with Chloroquine demonstrated that it is active against the trophozoites of Entamoeba histolytica. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.

  7. jguchkain Guest

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  8. babloved Well-Known Member

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  9. summlex Well-Known Member

    Taking Plaquenil for Rheumatoid Arthritis Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination.

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