I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Hydroxychloroquine mode of action Drug interaction zantac and chloroquine If side effects do occur, they are usually minor and last only for a short period of time. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Plaquenil, what to expect for the first time taking it. Skyllark • • 6 Replies. My wife will be taking Plaquenil for the first time, is there any things she should expect in taking it in starting to take the medication. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals. When I first started taking it, I had to always take it with food or I’d get nausea and yucky stomach feelings. Now I take it on an empty stomach with my coffee in the morning 😂 All in all, Plaquenil has been great for me. Very tolerable, and very helpful. I was able to go back to graduate school after getting to the right dose for me. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Rx Side Effects New Plaquenil Guidelines and More., Plaquenil, what to expect for the fir. - Hughes Syndrome Chloroquine dosing in infantsCardiomyopathy caused by plaquenilPlaquenil cause muscle painPlaquenil maculopathy aao Blurred vision may occur in the first few weeks. after starting hydroxychloroquine. This usually returns to normal even when you continue taking the tablets. Talk to your doctor if you are worried. Taking high doses 600 mg per day of. hydroxychloroquine over a long time more than five years can also cause damage to your retina, Hydroxychloroquine – what you can expect when starting.. My first appointment with the Rheumatologist and Plaquenil.. Let me tell you what weaning down from Plaquenil is like.. I have been taking plaquenil for a little over 10 years and getting eye exams regularly. Suddenly I'm experiencing eye problems blilnd spots. I have stopped taking plaquenil, but now I'm being told by doctors that the damage is not necessarily reversible especially if you have taken it for a long time. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. The Plaquenil is supposed to kick in in 3 to 6 months. I think it was 8 months for me. One day I was congratulating myself for getting so many things done and I realised that the days had been getting better without my noticing.