Affecting my self esteem Your definitely not alone. I’m fair hair n skin but I’m getting brown blotches. I am not looking to when it starts coming down my face hope I can b helped in time. Chloroquine ineffective on exoerythrocytic Half life of hydroxychloroquine How does plaquenil fight malaria Total synthesis of chloroquine Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. Improvement of the hyperpigmentation a few months after hydroxychloroquine is stopped has been reported, but complete clearance is rare.1 Cautious use of the Q-switched ruby laser has shown promise in the treatment of nonmelanotic hyperpigmentation in limited case reports.5 Our patient’s skin discoloration partially resolved four months after switching to chloroquine. Find information about common, infrequent and rare side effects of Hydroxychloroquine Oral. My scalp has turned black and my forehead side of face r slowly turning ears r totally black shiny plate .various long and boring treatments from docs but to no avail.finally I have been asked to stopped taking h for lupus for 3 next step will b decided. I am surprised to hear about this cos my rheumy said hydroxy helps to lighten the skin. One of them is on my nose and people keep telling me I’ve a dirt mark. I'm from Indian sub continent and am a "woman of colour like urself" approx 2 years ago had sudden deep painful itch in scalp and body. Yes I have been on this med since 2003 and I have black patches all over. Hydroxychloroquine skin discoloration Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine-related skin discoloration CMAJ Plaquenil generic vs name brandPlaquenil and cymbaltaHydroxychloroquine sulfate 200 mg dosage Age of people who have Skin discoloration - bluish when taking Hydroxychloroquine sulfate * 0-1 0.0 %. 2-9 0.0 %. 10-19 23.08 %. 20-29 0.0 %. 30-39 7.69 %. 40-49 15.38 %. 50-59 7.69 %. 60+ 46.15 %. Hydroxychloroquine sulfate and Skin discoloration - bluish.. Common and Rare Side Effects for Hydroxychloroquine Oral. Hydroquinone Skin Bleaching Topical Uses, Side Effects.. Apr 18, 2009 Re Plaquenil and skin discoloration Reply #11 on April 21, 2009, PM Hyper-pigmentation is a possible side effect of chloroquine medications, chloroquine binds with melanin, causing patchy or mottled spots on areas of skin exposed to sunlight. The long-term use of hydroxychloroquine in systemic lupus erythematosus treatment is associated with skin lesions in about 7%–29% of the patients.1 2 It usually involves the oral mucosa, shins, nails, forearms and anterior side of the legs.1 2 The time of onset ranges from few months to years after starting treatment, opposite to the ophthalmological adverse effects that are associated with duration and cumulative dose of hydroxychloroquine. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia.