Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing. Plaquenil information sheet Hydroxychloroquine handling Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in. Retinopathy, hyperpigmentation, myopathy, and skin reactions.1 Retinopathy Retinopathy’s irreversibility—the threat of permanent vision loss—and its substantial prevalence in patients with a large drug expo-. a Autoimmune retinopathy AIR is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoimmune disease in the patient or in a family member or the presence of neoplastic disease in the individual. The disease may be subdivided into paraneoplastic and non-paraneoplastic AIR. Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG). Hydroxychloroquine-mediated retinopathy Genetic Variants in Egyptian Patients Receiving HCQ., Hydroxychloroquine An old drug with new relevance Effects of ultraviolet ray on chloroquineTylenol and plaquenilNbme 15 chloroquine Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine - Wikipedia. Autoimmune retinopathy A Review International Journal of.. Hydroxychloroquine From Malaria to Autoimmunity SpringerLink. The risk of hydroxychloroquine-mediated retinal toxicity is relatively low within the first 5–10 years of therapy when used at daily doses that do not exceed 5 mg/kg, typically 200–400 mg daily. 1 Risk is clearly a balance between daily dose and duration of use, but there are little data available on the degree to which highly elevated doses can accelerate toxicity. Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer - Full Text View. Acute zonal occult outer retinopathy AZOOR is a retinal disease first described by Gass in 1992; reporting on 13 cases that shared the following features rapid loss of one or more large zones of outer retinal function, minimal fundus changes, electroretinographic abnormalities, and permanent visual field loss that was associated with delayed development of visible atrophic changes in the.