So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Chloroquine autophagy flux Plaquenil screening eye exam Hydroxychloroquine in lupus nephritis Plaquenil and immune system This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Here are some things that may reduce the risk of both the onset of lupus, in those who are at risk, and a flare-up. Hydroxychloroquine Plaquenil This is an antimalarial drug. It can help to. Does anyone know if you have to be weaned off Plaquenil? I've been on it for 15 years, for Lupus? Asked by Lupie523 Updated 27 September 2018 Topics plaquenil, lupus erythematosus, insomnia, sjogren's syndrome, systemic lupus erythematosus, vision Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Chances of having a lupus flare when stopping plaquenil Plaquenil Use in Autoimmune Diseases, Lupus Treatment, living with lupus, and prevention Hydroxychloroquine tablets side effectsChloroquine for alzheimer's disease treatment Stopping a prescribed medication like Plaquenil could feasibly cause a flare. Again, please speak clearly and often with your medical caregiver about any and all medication decisions. Ask as many questions as you need to make sure you feel comfortable and have a clear understanding of what you are taking and why. Lupus Flares Recognizing one, triggers, and prevention.. Does anyone know if you have to be weaned off Plaquenil? I've been on.. Had to stop taking Plaquenil -. Or shorter - up to 200 mg Plaquenil daily; Women with lupus who are AT OR BELOW their ideal body weight should go by these dosing rules 135 lbs. or more, any height - up to 400 mg Plaquenil daily; 102 lbs. to 134 lbs. - up to 300 mg Plaquenil daily; 101 lbs or less - up to 200 mg Plaquenil daily; A lupus patient explains her changes in vision Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. I have also been on Plaquenil for about 2 1/2 years. I have Lupus and Sjogrens. I have had a bad flare for about 3 months, doing some better now, but I also wondered if I wasn't back sliding. I felt so much better for a little over 2 years. I hurt so bad and am so tired and weak. I have to force myself to get anything done.