These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Plaquenil for autoimmune hives Can you donate blood if you take plaquenil Plaquenil eyesight Hydroxychloroquine 50 mg Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one year after therapy discontinuation L Katie Morrison MD 1,2, James J Nordlund MD 1, Michael P Heffernan MD 1 Dermatology Online Journal 15 12 15 1. Center for Clinical Studies, Houston, Texas 2. Wright State Dermatology, Dayton, Ohio Abstract I think it's due to Hydroxycholoroquine-induced hyperpigmentation an example of drug-induced skin pigmentation. I thought it worth showing those of you on the medication. Why is it so much worse on the right forearm? Well she's only just started to drive again. Hyperpigmentation of skin, mucosa, and nails can be observed in patients treated with antimalarials, including hydroxychloroquine. Elder abuse is a significant and underreported problem in seniors. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Hydroxychloroquine-Induced Pigmentation in Patients With., Plaquenil Pigmentation - BJC Health Chloroquine during early pregnancyHydroxychloroquine for dermatomyositisPlaquenil and prednisone combination Hydroxychloroquine-induced Hyperpigmentation of the Skin. J Rheumatol. 2015;421135-6. Jallouli M, Frances C, Piette JC, Huong du LT, Moguelet P, Factor C, et al. Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus a case-control study. Prevalence and risk factors of hyperpigmentation induced by.. Hyperpigmentation of the skin due to hydroxychloroquine.. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Lesions resemble ecchymoses that fail to resolve, and drug extravasation and binding to melanin is a theorized mechanism. Some cases are. Brown Skin Home / Skin / Pigmentation / Drug-Induced Pigmentation. Skin Drug-Induced Pigmentation. Women with brown skin, particularly those of African and Latino descent, have a high incidence of hypertension, diabetes and heart disease and consequently take medications for those medical problems.