Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine in amoebiasis Anti malaria medication plaquenil Effect of Chloroquine and Artesunate on Pathology in the Liver. haemosiderosis and hemozoin were observed in the liver. The effect of Artesunate at reducing the pathologies caused by the malaria parasite was more noticeable compared to that of Chloroquine. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Effects of chloroquine on the liver Hydroxychloroquine - Wikipedia, Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning What tier is plaquenilEffects of chloroquine on the liverPlaquenil drug information Since Chloroquine phosphate tablets are known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs. Central Nervous System Effects Chloroquine may increase the risk of convulsions in patients with a history of epilepsy. Drug Interactions Chloroquine - FDA prescribing information, side effects and uses. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Chloroquine DermNet NZ. To further confirm the dual effects of chloroquine on liver I/R injury, additional rats were subjected to 90 min of warm I/R. Chloroquine treatment caused a similar dual effect in terms of liver. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury. Effect of a single dose of chloroquine on antioxidant enzymes of rat liver and kidney. Each bar represents mean ± SD of triplicate determinations of five animals. All enzyme assays were done according to the procedures described in the text.