It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine blindness Plaquenil skin discoloration Plaquenil isn a antiparasitic drug with anti-inflammatory affect. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. Anyone taking plaquenil have heart palpitations? I've noticed my heart fluttering/skipping beats. Of course when I went in to the doctor/wore a 24 hr holter I didn't experience anything and nothing was going on. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil palpitations Plaquenil Hydroxychloroquine - Side Effects, Dosage., Plaquenil and heart palpitations? rheumatoid Side affects hydroxychloroquineCan i stop taking plaquenilField of vision test plaquenil Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Is extreme fatigue a side effect of Plaquenil?. Plaquenil Side Effects on Your Eyes and Vision. Has anyone experienced heart palpitations after taking.. Hi Snuttle, I had the same situation last month. After a week of it my DH insisted I go the E. R. There they did an EKG, stess test with an echogram, and, a heart cath. After all that it was decided that I was having irregular palpitations, but, it was considered "benign" because my heart showed no damage. I experienced heart palpitations & dizziness on another drug, not Plaquenil- actually had the ECG and Holter test last week but they were ordered by my cardiologist my rheumy wrote to them asking to investigate the palpitations. But, overall it has decreased the intensity of wicked palpitations, shortness of breath, joint pain, itching and frequent urination that I had with my flares. If any of them effect me now.are tolerable and as not concerning as they were in the past. So, I choose to believe that Plaquenil has changed this for me.