Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine with or without food Plaquenil and shingles vaccine ONCOLOGY REPORTS 35 43-49, 2016. Abstract. Recently, chloroquine CQ has been widely used to improve the efficacy of different chemotherapy drugs to treat tumors. However, the effects of single treatment of CQ on liver cancer have not been investigated. The use of chloroquine in combination with other chemotherapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, and inhibition of autophagy by chloroquine may sensitize not only cancer cells, but also normal organs to chemotherapy. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Chloroquine and liver cancer Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine in Cancer Therapy A Double-Edged Sword of. Hydroxychloroquine topicalOct image plaquenil toxicityFolic acid and hydroxychloroquine dosing sleGeneric plaquenil shortage Aug 19, 2014 Where and How Chloroquine Fights Cancer. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Where and How Chloroquine Fights Cancer Science Signaling. Chloroquine Indications, Side Effects, Warnings -. Porphyria Cutanea Tarda Pictures, Treatment, and More. The antimalarial agent chloroquine has been found to mitigate some of these challenges by modulating cancer cells and the tissue microenvironment. Particularly, chloroquine was recently found to reduce immunological clearance of nanoparticles by resident macrophages in the liver, leading to increased tumor accumulation of nanodrugs. Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy. Chloroquine feeding resulted in tumors located in the liver lymphosarcomas and primaquine in tumors in the kidney histiocytic sarcomas. Toads fed chloroquine plus primaquine developed tumors in the liver, kidney, lung, and urinary bladder, and all the tumors were diagnosed as histiocytic sarcomas.