Can plaquenil cause visual field

Discussion in 'Chloroquine' started by mylink, 07-Mar-2020.

  1. fibola Well-Known Member

    Can plaquenil cause visual field


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Apr 20, 2011 Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3 The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. An unusual form of the toxicity causes peripheral constriction of the visual field. Monthly ophthalmic exams are recommended for doses of ethambutol exceeding 15 mg/kg/day. Fluoroquinolones are associated with side effects not seen in other classes of antibiotics. Topical administration may cause precipitates in the cornea and, possibly, uveitis. This has similar sensitivity to visual fields and can provide objective confirmation of suspected paracentral field loss. Fundus Autofluorescence FAF Early hydroxychloroquine toxicity can also be detected on autofluorescence as an increased ring of signal within the parafoveal and extramacular regions, which is indicative of photoreceptor dysfunction and RPE dysfunction.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Can plaquenil cause visual field

    What can Hydroxychloroquine Plaquenil do to my eyes?, Rx Side Effects New Plaquenil Guidelines and More - American.

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  7. Nov 18, 2011 Although visual field defects in HCQ toxicity can be highly variable in terms of the depth of defect, all our patients showed a similar pattern on 10-2 white, with the same areas affected. However, one needs to look carefully for subtle decreases in threshold in the area at risk 2–6 degrees from center.

    • Humphrey visual field findings in hydroxychloroquine toxicity.
    • Hydroxychloroquine Plaquenil Toxicity and..
    • Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS.

    Visual Fields Early drug toxicity can cause bilateral, relative paracentral scotomas4 Defects can be present BEFORE definitive signs are seen on fundus examination. A white-on-white 10-2 threshold visual field is recommended.19 • Want to pay close attention 2-6 degrees from fixation21 Visual field tests in addition to optic nerve imaging are also used to monitor glaucoma, and it will also decrease your visual field, as plaquenil can. I'm no longer taking the plaquenil, but opthamologist is insistent on following me for possible glaucoma. Hence, I still get a visual field test and optic nerve imaging study done every year. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2

     
  8. lerucencia Well-Known Member

    I am taking a course of rabies immunizations, and the typical recommended dose is four shots over time. Hydroxychloroquine Plaquenil Medications that Weaken Your Immune System and Fungal. Will you have Immunodeficiency disorders with Plaquenil.
     
  9. Chloroquine And Hydroxychloroquine Toxicity - StatPearls - NCBI Bookshelf Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time.

    When ‘Collateral Damage’ Strikes the Cornea
     
  10. TiLL Well-Known Member

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