Treatment of porphyria cutanea tarda with chloroquine

Discussion in 'Chloroquine' started by roma095, 01-Mar-2020.

  1. BeginerF New Member

    Treatment of porphyria cutanea tarda with chloroquine


    Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT.

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    Seven patients with porphyria cutanea tarda received a total of ten courses of low-dose oral chloroquine therapy 125 mg chloroquine phosphate twice weekly. Patients were treated for a mean 14.9 months during which time all went into clinical and biochemical remission. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. Br J Dermatol. 1987 Mar. 1163407-15. Bruce AJ, Ahmed I. Childhood-onset porphyria cutanea tarda successful therapy with low-dose hydroxychloroquine Plaquenil.

    Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT".

    Treatment of porphyria cutanea tarda with chloroquine

    Porphyria Cutanea Tarda - Pictures, Diagnosis, Causes, Treatment, Hydroxychloroquine DermNet NZ

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  7. Dec 20, 2019 Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine.

    • Porphyria Cutanea Tarda Treatment & Management Medical Care..
    • Porphyria Cutanea Tarda Treatment & Management Medical..
    • Treatment of Porphyria cutanea tarda - News Medical.

    Porphyria cutanea tarda PCT is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase UROD is deficient. Approximately 80% of all cases of porphyria cutanea tarda are acquired; 20% are familial, although the ratio may vary among different geographic regi. Nov 18, 2017 Treatment of acute porphyria attacks focuses on providing rapid treatment of symptoms and preventing complications. Treatment may include Injections of hemin, a medication that is a form of heme, to limit the body's production of porphyrins; Intravenous sugar glucose, or sugar taken by mouth, if able, to maintain an adequate intake of carbohydrates If you have cutaneous porphyria, your treatment will depend on the specific type of the disease you have and how severe your symptoms are. If you have porphyria cutanea tarda, your treatment might include Regular removal of your blood to lower the amount of iron in your liver. This is called phlebotomy.

     
  8. teenwor Guest

    Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1]. Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer. Metastatic cells are preferentially vulnerable to lysosomal inhibition. Leaving the lysosome behind novel developments in autophagy.
     
  9. Xelas User

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine User Reviews for Lyme Disease, Arthritis. Hydroxychloroquine - Wikipedia Hydroxychloroquine Uses, Dosage & Side Effects -
     
  10. Mechanisms of action of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases. Multiple mechanisms might explain the efficacy and adverse effects of these drugs.

    Hydroxychloroquine - Wikipedia