Chloroquine phospahe absorbance nm

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  1. shalsung Moderator

    Chloroquine phospahe absorbance nm


    The method consists of recording the UV absorbance of the sample at a wavelength of 343 nm and comparing it to the absorbance of a reference standard in a concentration range representing a 100% label claim at the same wavelength. The method was adapted in such a way that it was possible to determine the quantity of the different salt forms of chloroquine in the tablets, where applicable.

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    Aug 22, 2005 Background. Severe acute respiratory syndrome SARS is an emerging disease that was first reported in Guangdong Province, China, in late 2002. The disease rapidly spread to at least 30 countries within months of its first appearance, and concerted worldwide efforts led to the identification of the etiological agent as SARS coronavirus SARS-CoV, a novel member of the family Coronaviridae. Kg or more 1 g chloroquine phosphate 600 mg base orally as an initial dose, followed by 500 mg chloroquine phosphate 300 mg base orally after 6 to 8 hours, then 500 mg chloroquine phosphate 300 mg base orally once a day on the next 2 consecutive days Total dose 2.5 g chloroquine phosphate 1.5 g base in 3 days Less than 60 kg Analytical wavelength343 nm bile phase to obtain a solution having a known concentra-Standard solutionUSP Chloroquine Phosphate RS in tion of about 1.5µg per mL. Medium Test solution—Proceed as directed for Assay preparation in Sample solutionDilute with Medium to a concentrationthe Assay. that is similar to the Standard solution.

    Interference from excipients was validated by superimposing the UV spectra of the sample and standard. As all USP methods are specific for the analyte, the method was only validated in terms of precision.

    Chloroquine phospahe absorbance nm

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  3. The content of chloroquine was determined by UV-spectrophotometry in accordance with an adapted method for chloroquine phosphate tablets of the USP 24. The method consists of recording the UV absorbance of the sample at a wavelength of 343 nm and comparing it to the absorbance of a reference standard in a concentration range representing a 100%.

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    Absorptivity ∆A is directly related to concentration. ∆A = Chloroquine in acidic medium is scanned over UV region by taking basic drug solution as blank. From the absorbance values, Two wave lengths are selected one at 285 nm positive peak and another at 345 nm negative peak. Nm in method A and at 430 nm in method B. The details about the reaction chemistry, method development and validation as well as applications of all the methods are presented in this Section 8.1. 8.1.2.0 EXPERIMENTAL 8.1.2.1 Apparatus The instrument used for absorbance measurements was the same as described in Section 2.1.2.1. Medscape - Indication-specific dosing for Aralen, Chloroquine phosphate chloroquine, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.

     
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