Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and sulfasalazine combination Can plaquenil cause liver damage Another thing I should say. The Plaquenil is used to treat the Sjogren's, not directly treat the neuropathy. If she feels the neuropathy is caused by the Sjogren's, then I guess she feels treating the underlining cause will help the SFN. It's actually not very effective in this manner. The cause of most cases of small-fiber neuropathy is uncertain, but many patients have accompanying autoimmune biomarkers. In a carefully selected group of such patients, intravenous immunoglobulin treatment appears to provide benefit. Did your muscle pain come before, after or with the neuropathy? Did the Plaquenil help with the muscle joint part of your problem? Where was your neuropathy and what are you taking now if anything? When I took the Plaquenil I had RA antibodies and it was muscle / joint related. Thanks for responding. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause neuropathy Hydroxychloroquine Sulfate Neuropathy Peripheral Reports., Treatment for Autoimmune Small-fiber Neuropathy 2018-02-16. Plaquenil and curcuminDoes plaquenil change heart rate Mutations in the SCN9A or SCN10A gene can cause small fiber neuropathy. These genes provide instructions for making pieces the alpha subunits of sodium channels. The SCN9A gene instructs the production of the alpha subunit for the NaV1.7 sodium channel and the SCN10A gene instructs the production of the alpha subunit for the NaV1.8 sodium channel. Small fiber neuropathy - Genetics Home Reference - NIH. Plaquenil and small fiber neuropathy - NeuroTalk Support Groups. Ask the Expert Plaquenil and Sjögren’s. In doing so, we compare PLAQUENIL with other drugs that cause NEUROPATHY, to help you evaluate whether or not PLAQUENIL causes NEUROPATHY. Likewise, this page shows the most highly-reported side effects of PLAQUENIL, so you can see if NEUROPATHY ranks among PLAQUENIL's most well-known side effects. One of the first medications used to treat that problem is hydroxychloroquine or Plaquenil. Although hydroxychloroquine can cause hair loss, it is rather unusual. In general, when my patients are on hydroxychloroquine and have new-onset hair loss, we often search for other causes before we ascribe the hair loss to hydroxychloroquine. Find information about common, infrequent and rare side effects of Plaquenil Oral.