Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Hydroxychloroquine birth defects Oct plaquenil screening Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. Topiramate Topamax is used to treat epilepsy and migraines. The drug also is used off-label for a number of concerns, including weight loss, bipolar disorder and depression. It has been associated with acute angle-closure glaucoma and transient myopia. Statins may be associated with diplopia. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Hydroxychloroquine side effects weight loss HYDROXYCHLOROQUINE - ORAL Plaquenil side effects., Plaquenil & Weight Gain/Loss - Hydroxychloroquine pigmentationIs chloroquine safe during pregnancyAralen 150 mg These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Rx Side Effects New Plaquenil Guidelines and More.. Hydroxychloroquine Side-effects, uses, time to work. Summary Weight loss is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 2-9 old, have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Juvenile rheumatoid arthritis. Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Approximately 23% of the treated patients showed abnormal weight gain P = 0.001. Patients treated with doxycycline and hydroxychloroquine presented significantly lower concentrations of Bacteroidetes P = 0.002, Firmicutes P = 0.01, and Lactobacillus P = 0.02.