Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Chloroquine mw Plaquenil and rheumatoid arthritis reviews Plaquenil schedule Whorl keratopathy plaquenil Antimalarials- Quinine & Chloroquine- Ototoxic effect is due to vasoconstriction in the small vessels of the cochlea and stria vascularis.- The effect is reversible which generally appears on prolonged medication, but deafness is permanent with chloroquine.- Certain painkillers and fever reducers salicylates, quinine, chloroquine; Ototoxic medications can affect everybody regardless of factors like age or gender. Fortunately, not everybody who takes one of these drugs will experience ototoxic side effects. Chloroquine CQ, a 4-aminoquinoline drug, has been largely used for the treatment of rheumatoid arthritis and other connective tissue diseases. Besides the well-known retinal toxicity, its use has been suspected of be associated to ototoxicity. Some reports have described mainly sensorineural hearing loss, tinnitus, sense of imbalance, and cochleovestibular manifestations. Differently from. The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses. Chloroquine ototoxicity Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy, Why You Should Care About Ototoxic Medications The MED-EL Blog Chloroquine suicideIs plaquenil used for mixed connectivity tissue disorder There are some reports about chloroquine-induced ototoxicity 7-9. Severe chloroquine-induced cochleovestibular toxicity was reported in a pregnant woman. Absence of inner and outer hair cells of the cochlea was also detected in a child whose mother took chloroquine during her pregnancy. A case report of hearing loss post use of hydroxychloroquine.. Chloroquine ototoxicity SpringerLink. Ototoxicity Vestibular Disorders Association. Ototoxicity at therapeutic doses is limited Aminoglycosidic antibiotics e.g. streptomycin, gentamycin and some other antibiotics e.g. tetracyclines, Loop diuretics* e.g. furosemide, ethacrynic acid Certain analgesics* and antipyretics* salicylates, quinine, chloroquine Most important agents to cause irreversible ototoxicity are Aminoglycosides and Cisplatin. FACTORS INFLUENCING OTOTOXOCITY Drug concentration in inner ear Dose, Absorption, Clearance from body, Selectivity to ear Intolerance Renal and hepatic disease Placental transport Chloroquine, Streptomycin can lead to ototoxicity in fetus Genetic. Chloroquine should be used with caution in patients with neurological disease including preexisting hearing impairment or seizure disorder. Polyneuritis, ototoxicity, seizures, neuromyopathy, and acute extrapyramidal symptoms dystonia, dyskinesia, tongue protrusion, torticollis have occurred with chloroquine therapy.