Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Malaria chloroquine primaquine and chloroquine phosphate Plaquenil mouth ulcers Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Went like this back and forth and it was definitely the medicine. Also I started to feel worse while taking it. It could be that the weather is getting colder and that always makes me feel worse. but we decided I couldn't tolerate an increase in dosage which was what would have been next on the treatment plan so we moved on to something else. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine makes me feel worse Hydroxychloroquine Reviews Everyday Health, User Reviews for Hydroxychloroquine to treat. - Rogaine for plaquenil hair lossIs plaquenil used to treat ms I started plaquenil 1.5 weeks ago, on the day my period started, so I haven't been on it for that long. I was just noticing, however, that I am NOT experiencing the intense ovulation cramps that have been plaguing me for a while I feel a teensie amt of discomfort, instead. Irritability and increased hot flashes with Plaquenil. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. I asked her for plaquenil since it's a non steroid anti inflammatory. She seemed hesitant to prescribe it. She told me that it could make me feel better or much much worse. She said after 3 days of burbur detox I could try 1/2 tablet of plaquenil every other day, but if i start feeling worse to stop immediately. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. I have been on it for about. 3 months now. At first, I was nauseous for a week or so, which the dr. told me could be a side effect. After the nausea went away it seemed like my pain got worse for a week or so, and then it gradually got better.