Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Molecular weight of chloroquine phosphate Adverse effects of plaquenil Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Are there any reasons I won't be prescribed hydroxychloroquine? Before starting on hydroxychloroquine your doctor may take a blood test to check that your liver and kidneys are working normally, but you won't need any regular blood tests during the treatment. Medication side effects Two patients experienced medication side effects. One 6.7% in methotrexate group who showed elevated liver enzymes and the other 7.1% in hydroxychloroquine group who demonstrated drug eruption. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Methotrexate and hydroxychloroquine side effects Hydroxychloroquine - Side Effects, Dosage, Interactions., Clinical efficacy and safety of methotrexate versus hydroxychloroquine. Chloroquine cost boots Ocular side effects of anti-rheumatic medications what a rheumatologist should know. either nutritional or genetic. 89 Folate supplementation when co-administered with methotrexate, minimizes its adverse effects 90 and may therefore prevent the development of optic neuropathy. Chloroquine and hydroxychloroquine have been used to treat. Ocular side effects of anti-rheumatic medications what a.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Effects of methotrexate and hydroxychloroquine combination therapy vs.. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. Side Effects Prevention Tips. The good news These common side effects can often be short-circuited by taking a folic acid supplement. Folic acid is the synthetic form of folate. One study found that rheumatoid arthritis RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent. These side effects can be improved with folic acid supplementation. Folic acid given at a dose of 1mg daily does not diminish the efficacy of methotrexate and is routinely given with methotrexate to decrease these side effects. Some patients complain of headache, fatigue, and feeling “wiped out” also called methotrexate “fog”.