Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Does plaquenil come as an injection If hydroxychloroquine was ineffective would it be effective with methotrexate Protecting your eyesight when taking Plaquenil With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. Plaquenil comes in tablet form. It is taken once a week to prevent malaria, starting two weeks before anticipated exposure and continuing until four to eight weeks after you return from the high-risk area. For other uses, it is usually taken once or twice a day. I normally post on the arthritis board, and due to toxicity of the Plaquenil after 2 years, I have had to discontinue it, since I failed the visual field testing. Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. When is it best to take plaquenil Hydroxychloroquine Plaquenil, What You Need to Know About Plaquenil Plaquenil decrease immune systemHydroxychloroquine metabolism I have just been reading that plaquenil can cause insomnia and nightmares which I suffer with. I take my plaquenil with my evening meal. When is the best time to take it? Would it be best in the morning? I also take in the morning thyroxine, omeprazole and co-codamol, would it interfere with any of those if I took it in the morning instead of. When best time of day to take plaquenil? - LUPUS UK. Discontinued Plaquenil.other options?. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. I actually take all 400 mg in the morning after eating breakfast because after my stomach adjusted, I have tolerated the Plaquenil very well. My rheumy doesn't think there's a problem with taking it all at once as long as I'm tolerating it since there is such a long half-life, it shouldn't affect the drug itself. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.