Chloroquin and ferroquine structure

Discussion in 'Health Canada Drug Database' started by uzsky, 05-Mar-2020.

  1. Promoweb New Member

    Chloroquin and ferroquine structure


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Chloroquine half life mouse Side effects of hydroxychloroquine for ra

    This study explains malaria origin and presents Plasmodium evolution and chloroquine mode of action on parasite. Hypotheses on the chloroquine resistance mechanism and reversion of antimalarial. Aug 15, 2011 Ferroquine FQ, SSR97193 is currently the most advanced organometallic drug candidate and about to complete phase II clinical trials as a treatment for uncomplicated malaria. This ferrocenecontaining compound is active against both chloroquine-susceptible and chloroquine-resistant Plasmodium falciparum and P. vivax strains and/or isolates. Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine CQ but cannot fully explain the activity of ferroquine FQ which has been related to redox properties and intramolecular hydrogen bonding. Analogues of FQ, methylferroquine Me-FQ, ruthenoquine RQ, and methylruthenoquine Me-RQ, were prepared.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquin and ferroquine structure

    Structure Activity Relationship of CHLOROQUINE, The antimalarial ferroquine from bench to clinic

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  5. Nov 21, 2017 Here we present ferroquine FQ, the next generation antimalarial drug, as a promising candidate for repositioning as cancer therapeutics. We report that FQ potently inhibits autophagy, perturbs lysosomal function and impairs prostate tumor growth in vivo.

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    Ferroquine FQ, or SSR97193, is a novel antimalarial drug currently in phase I clinical trials. FQ is a unique organometallic compound designed to overcome the chloroquine CQ resistance problem. FQ revealed to be equally active on CQ-sensitive and CQ-resistant Plasmodium falciparum laboratory strains and field isolates. FQ is also curative on rodent malaria parasites. As FQ will be tested. Currently ferroquine which contains elements of ferrocene and chloroquine, is undergoing evaluation as a commercial antimalarial drug. Furthermore, ferrocifen, which is based on the elements of ferrocene and tamoxifen, is currently undergoing clinical trials as a potential breast cancer drug. Ferroquine, an Ingenious Antimalarial Drug –Thoughts on the Mechanism of Action Faustine Dubar 1, Jamal Khalife 2, Jacques Brocard 1, Daniel Dive 2 and Christophe Biot 1, * 1 Université des Sciences et Technologies de Lille, Unité de Catalyse et Chimie du Solide – UMR

     
  6. divp Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. PATIENT FACT SHEET Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil Hydroxychloroquine MedlinePlus Drug Information
     
  7. Login0FF Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs Hydroxychloroquine Uses, Dosage & Side Effects - Hydroxychloroquine - Side Effects, Dosage, Interactions.
     
  8. BlizzPSL Well-Known Member

    Hydroxychloroquine Plaquenil Although there are few drug interactions with hydroxychloroquine, to be safe be sure to tell your doctor about all of the medications you are taking, including over-the-counter drugs and natural remedies. Be sure to notify your other physicians when taking this drug.

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