Long-term progression of hydroxychloroquine retinopathy off the drug

Discussion in 'Health Canada Drug Database' started by others, 09-Mar-2020.

  1. YSAq XenForo Moderator

    Long-term progression of hydroxychloroquine retinopathy off the drug

    Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

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    Later damage, as toxicity evolved to a severe stage, was diffuse across most of the macula. If the drug was stopped at an early or moderate stage, progression was limited to the first year and occurred diffusely without parafoveal localization. CONCLUSIONS Hydroxychloroquine retinopathy primarily involves outer retina photoreceptors. Pham B, et al. Long-term progression of hydroxychloroquine retinopathy off the drug. Presented at Association for Research in Vision and Ophthalmology annual meeting; April 29-May 3, 2018; Honolulu. Nevertheless, retinopathy begins to appear with long-term use, and retinopathy is serious insofar as there is no known treatment. It can progress for a year or more after stopping the drug and, if not recognized early at the point of screening, it can lead to functional blindness.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Long-term progression of hydroxychloroquine retinopathy off the drug

    Determine risk for hydroxychloroquine retinal toxicity., Despite Plaquenil dosing recommendations, retinal toxicity.

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  7. IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy.

    • The risk of toxic retinopathy in patients on long-term..
    • Hydroxychloroquine Retinopathy Still Alive and Well - The Rheumatologist.
    • The Risk of Toxic Retinopathy in Patients on Long-term..

    The present study reports data on 11 cases of hydroxychloroquine retinopathy that were monitored for 13 to 51 months after cessation of the drug. These cases are identical, with those studied previously with clinical data, although several now have a longer period of follow-up. Chloroquine retinopathy, is a form of toxic retinopathy caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

  8. parkdubki New Member

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Chloroquine resistant Plasmodium vivax review Worldwide. Chloroquine - an overview ScienceDirect Topics Chloroquine - FDA prescribing information, side effects and uses
  9. VVG Guest

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine MedlinePlus Drug Information Is Chloroquine a Cure for Coronavirus? Scientists Say Maybe. Hydroxychloroquine Plaquenil — Canadian Hair Loss Foundation
  10. teska Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for. Lupus Systemic Lupus Erythematosus or SLE Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More
  11. beee XenForo Moderator

    Melatonin" Lupus Community - Support Group Hi, Wondered if anyone has experience, negative or positive, wiht melatonin. I've been having sleep issues and really would rather not go the pharmceutical route. I used to take melatonin occasionally, but am concerned that perhaps it might not be advisable for lupus patients. My rheumy did not seem concerned when I mentioned it.

    Insomnia because of plaquenil DailyStrength