Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Indication of chloroquine Plaquenil cause muscle pain Apr 26, 2017 Alcohol can cause liver failure and cirrhosis. Methotrexate can also cause liver inflammation and fibrosis/cirrhosis. So combining the two doesn’t sound like such a hot idea. It turns out the answer to the question isn’t so black and white. Yes, alcohol can cause liver failure, however. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. You can take methotrexate in pill form or by injection, usually as a single dose once a week. 2. Why Should You Avoid Alcohol While Taking Methotrexate? Both alcohol and methotrexate affect your liver, so the two of them combined increases the potential for liver damage, says rheumatologist Vinicius Domingues, MD, CreakyJoints medical advisor. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Methotrexate plaquenil and alcohol Methotrexate vs Plaquenil Comparison -, Hydroxychloroquine Side Effects, Dosage, Uses, and More Plaquenil tendon pain Whether you take beverages shaken, stirred or decanted, mixing alcohol with methotrexate may deliver more than a hangover. Combining the two can create a cocktail muddled with serious side effects, says Junko Takeshita, M. D. Ph. D. with the department of dermatology at the University of Pennsylvania. Methotrexate and alcohol Tips for you National Psoriasis.. Drinking Alcohol While Taking Methotrexate Is It Safe?. RA, Methotrexate and Alcohol May Mix Well, to a Degree Rheumatology.. The 1994 American College of Rheumatology treatment guidelines for rheumatoid arthritis recommend that patients taking methotrexate abstain from drinking alcohol, but in 2008, the British Society for Rheumatology recommended just limiting alcohol intake in these cases. Moderate drinkers not at risk when taking a widely-used arthritis medicine. People who take methotrexate are often advised to abstain from alcohol as both methotrexate and alcohol are known to. National guidelines recommend that patients taking low-dose weekly methotrexate by any route of administration should ensure their consumption of alcohol is well within maximum national limits two to three units a day for women and three to four units a day for men, with at least one or two alcohol-free days per week.