Plaquenil treatment for vasculitis

Discussion in 'Health Canada Drug Database' started by QLE.RU, 02-Mar-2020.

  1. lesio XenForo Moderator

    Plaquenil treatment for vasculitis


    Listing a study does not mean it has been evaluated by the U. Hydroxychloroquine and is an established, effective, safe and inexpensive therapy, widely used in other autoimmune diseases such as lupus and rheumatoid arthritis. The study is open to adults diagnosed with certain types of vasculitis, called Granulomatosis Polyangiitis (GPA), Microscopic Polyangiitis (MPA) or Eosinophilic Granulomatosis with Polyangiitis (EGPA).

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    Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Cutaneous symptoms of urticarial vasculitis are treated with oral antihistamines and can also require non-steroidal anti-inflammatory drugs, oral corticosteroids, colchicine, chloroquine and/or dapsone. A subset of hypocomplementemic urticarial vasculitis may respond to Plaquenil. Current EULAR recommendations suggest that Plaquenil be considered as an adjunctive treatment in chronic but not acute calcium pyrophosphate deposition CPPD arthropathy. 18

    Participants will be randomly placed in 1 of 2 groups. One group will receive hydroxychloroquine and the other will receive placebo. 76 ANCA Vasculitis participants will be recruited (38 in each treatment arm) from UK vasculitis specialist centres over 2 years. Participants will be eligible if they are treated with background medication to control their vasculitis disease and have a low level of disease activity as defined by a Birmingham Vasculitis Activity Score (BVAS) of greater than 3.

    Plaquenil treatment for vasculitis

    Vasculitis and Lupus Lupus Foundation of America, Normocomplementaemic urticarial vasculitis effective.

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  4. Is Plaquenil helpful for Urticarial Vasculitis? can Plaquenil cause Urticarial Vasculitis? Plaquenil is mentioned in 43 posts about Urticarial Vasculitis.

    • Plaquenil and Urticarial Vasculitis - Reviews.
    • Plaquenil From Malaria Treatment to Managing Lupus, RA..
    • ANCA Vasculitis UNC Kidney Center.

    Vasculitis is considered to be a significant extraglandular manifestation of Sjögren’s syndrome SS. While a specific type of vasculitis has not been universally associated with SS, several sub-types of vasculitis occur with considerable frequency in SS. The treatment of most systemic so-call “extra-glandular manifestations” involves a hierarchy of treatments, starting with those appropriate for milder disease and ending with those for more severe disease. 1. Arthritis is initially treated with hydroxychloroquine with or without non-steroidal anti-inflammatory agents. More severe. For cases of urticarial vasculitis that are resistant to treatment with corticosteroids other immunosuppressive agents such as azathioprine, cyclophosphamide or ciclosporin may be considered.

     
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    PACKAGE LEAFLET: INFORMATION FOR THE USER Hydroxychloroquine Sulphate 200mg Film Coated Tablets (referred to as Hydroxychloroquine Sulphate Tablets in the remainder of the leaflet) Hydroxychloroquine sulphate Read all of this leaflet carefully before you start to take this medicine. You may need to read it again while you are receiving your treatment. It may harm them, even if their symptoms are the same as yours. Eye screening for patients taking hydroxychloroquine. Audit of the use of hydroxychloroquine in rheumatology. HYDROXYCHLOROQUINE
     
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