It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. I hate heart burn:( I take a PPI (proton pump inhibitor) essentially antacid in the morning that is supposed to last all day. I would ask your pharmacist first and see if it matters whether it is just a 'tums' or medication strength. I think if it keeps happening I’ll go talk to my pharmacist to see what they recommend. Has anyone else experienced heartburn while taking Plaquenil and if so what did you do to avoid or ease the heartburn? If they are not able to give you an answer your Family Dr or Rheumatoid will know. Fortunately the heartburn goes away after a few hours, but those few hours are very uncomfortable! Lysosomal acidification chloroquine Fluoroquinolone use and chloroquine resistance development Does Tums Interact with other Medications. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Swallow the tablet whole. Do not crush, break, or chew it. Take this medicine with meals or milk to lessen stomach upset, unless otherwise directed by your doctor. Feb 24, 2008 The reason for not taking antacids for an hour or so either side of taking Plaquenil is that they reduce absorption I think it's the same for other meds not just Plaquenil. And of course for herbals, supplements and even foodstuffs in some cases like grapefruit juice. But that's just the optimum way to take it, not the necessity. Sometimes what is suggested (no antacid for 4 hours) is not necessarily required if it means you can't or don't want to take your plaquenil anymore. the antacid will affect the absorption of the plaquenil and the amount your body can absorb. Can i take tums with plaquenil Hypothyroidism Can calcium supplements interfere with., Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Chloroquine descriptionRa hydroxychloroquine Mg 310 mg base PO once every 7 days. Alternatively, 6.5 mg/kg/dose 5 mg base/kg/dose; Max 400 mg/dose or 310 mg base/dose. Dosing should begin 2 weeks before entering and continue for 4 weeks after leaving the endemic area. The CDC suggests hydroxychloroquine as an alternative to chloroquine. Plaquenil hydroxychloroquine sulfate dose, indications.. Plaquenil & other drug interactions ? Lupus Forums at The.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Can I take zantac while taking methotrexate and plaquenil? Asked by margmac Updated 13 January 2015 Topics plaquenil, zantac, rheumatoid arthritis, methotrexate, antacid, stomach, contraindication. I have an acid stomach and need to take an antacid need help to choose one that won't be a contraindication. Take Plaquenil exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. Smoking can decrease the effectiveness of medications like cimetidine Tagamet and alters stomach contents, making them more acidic, but it also decreases lower esophageal pressure, making us more susceptible to reflux. 3. Avoid large, high-fat meals These meals tend to be heavy in the stomach and are slow to digest. This delay prolongs acid.