So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Plaquenil and sleep apnea Hydroxychloroquine prophylaxis SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. When the physician looked inside, he saw both pink and peach tablets, some split in half. Initially, the patient had been taking a 20-mg tablet twice daily. When the physician lowered the dose to 10 mg twice daily, the new prescription was filled. Overall Plaquenil did take away the muscle and joint pain. It worked wonders for that. For that reason I am satisfied with plaquenil for what I took it for. Took about 5-6 months to see full effect. Since reducing the dose from 400mg to 200mg 4 months ago I do feel some of this pain returning You win some, you lose some! M 49 1 years 400mg day Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Can you break plaquenil in half Healthboards - Immune & Autoimmune - Lupus Plaquenil Toxicity, Tablet Splitting—Only If You “Half” To Hydroxychloroquine forum Most time-released, long-acting, and combination drugs shouldn’t be split because it’s difficult to make sure that you’ll get the proper amount of the active ingredient in each half. When It's Safe to Split Pills - Consumer Reports. PLAQUENIL Side Effects, Reviews by Patients -. Tried plaquenil 200mg 2 tablets at once and got very sick.. Hi GeorgiaGirl, I have been taking plaquenil for about 4 years now. When I was first prescribed it I was scared to death to take it as well. I read about all the eye problems and I was worried I would go blind. After things got so bad with me I started taking it and I went thru what I know now to be a really bad herx. Plaquenil, a warning. Hello all, My wife had Lupus and was taking Plaquenil 200mg daily. If you’re having issues with Plaquenil. I literally just spent half the day doing normal girl things with my niece and now I'm lying in bed wanting to just die of pain. I feel like I'm on the verge of a breakdown because I want to feel normal again. Plaquenil hydroxychloroquine Even though you dont have a rash Plaquenil hydroxychloroquine can be responsible for your itchy hands and feet. Consult your doctor for help. Consult your doctor for help.