One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil 200mg tablets 100 Plaquenil injections Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. Macular degeneration is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take medication Humira, and have Joint deposit. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Macular oct for plaquenil Plaquenil Toxicity - Retina Image Bank, Will you have Macular degeneration with Plaquenil - eHealthMe Hydroxychloroquine metforminNon aqueous titration of chloroquine phosphateDoes plaquenil work like anxiety meds H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible. Retinal Physician - Hydroxychloroquine Maculopathy An.. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is relatively rare, estimated at 1 percent after five years and rising with continued therapy. 3 However. Chloroquine and hydroxychloroquine are known to disrupt lysosomal function of the RPE, leading to increased accumulation of lipofuscin. 26,27 Daily phagocystosis of photoreceptor outer segments occurs in the lysosomal apparatus of the RPE, and alterations in RPE metabolism may play a role in retinal toxicity. Retinal toxicity from hydroxychloroquine use cannot be completely prevented, but effective screening should recognize retinal toxicity before symptoms or significant risk of central vision loss appear ie, before the appearance of bull’s eye maculopathy. Screening requires the use of tests, such as 10–2 visual fields and SD-OCT and.