It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Can you get high on hydroxychloroquine Chloroquine base lethal dose Plaquenil arthritis medication Nov 16, 2017 I have been diagnosed with seronegative spondyloarthropathy and before that psoriatic arthritis. I have bilateral joint pain and SI joint issues. Just wondering if anyone out there has been put on plaquenil. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil arthritis pain Inflammatory Osteoarthritis And Plaquenil, Taking Plaquenil for Rheumatoid Arthritis Risk of plaquenil toxicityChloroquine vs hydroxychloroquinePlaquenil y alcohol Rheumatoid Arthritis Support Group. Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. Plaquenil for fatigue and pain DailyStrength. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Rheumatoid Drug No Help To Arthritis Patients. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Hydroxychloroquine Plaquenil – American College of Rheumatology – It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. It may prevent joint damage and reduce the risk of long-term disability. In severe cases, rheumatoid arthritis can cause pain throughout your entire body, including Muscle aches. Fatigue. Malaise. Poor appetite. Depression.