Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available. Pros and cons of plaquenil Buy chloroquine phosphate Hydroxychloroquine lupus treatment Adults—At first, 1000 milligrams mg once a day. Then, 500 mg 6 to 8 hours after the first dose, and 500 mg on the second and third days of treatment. Adults with low body weight and children—Dose is based on body weight and must be determined by your doctor. At first, 10 milligram mg per kilogram kg of body weight. If part or all of a dose is vomited within 1 hour, the same amount must be readministered immediately. Adults 500 mg equivalent to quinine sulfate dihydrate 600 mg every 8 hours for 3, 7 or 10 days. Children 8.2 mg equivalent to quinine sulfate dihydrate 10 mg/kg every 8 hours for 3, 7 or 10 days. Recommended prophylactic dose is about 5 mg/kg maximum 250 mg/dose orally once a week. -This drug should be taken on the same day of each week, preferably after the main meal. -Prophylaxis should begin 1 week before arrival in an endemic area, continue during the stay, and then continue for 4 weeks after leaving the area. Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only. Chloroquine dose per kg Chloroquine phosphate REEF2REEF Saltwater and Reef Aquarium., WHO Model Prescribing Information Drugs Used in Parasitic. Vision loss with plaquenilHydroxychloroquine for dermatomyositis Chloroquine phosphate is dispensed as a 250 mg tablet, which is equivalent to 155 mg chloroquine base. Long-term chloroquine use should aim for 2.3 mg/kg/day based on the patient's actual body weight. Given the tablet size, this usually means it needs to be used intermittently; that is, several times per week instead of daily. Chloroquine DermNet NZ. Mefloquine Dosage Guide with Precautions -. Aralen, Chloroquine phosphate chloroquine dosing.. Fourth dose 36 hours after first dose 8.3 mg chloroquine phosphate/kg 5 mg base/kg orally. Total dose 41.7 mg chloroquine phosphate/kg 25 mg base/kg in 3 days. Comments -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae. A metabolite of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. The Weight Based Dose Calculator is used for weight based dosing. The parameters for the calculator include dosage, weight, med amount, per volume.