Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil alopecia areata alopecia totalis Is hydroxychloroquine an opiate Symptoms of hydroxychloroquine Hydroxychloroquine nsaid Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1 – 5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals 6. The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile. The plasma half-life is 32-50 days. Although some of the pigmentary effects are known to be dose dependent, in most cases dyschromia does not appear to be related to cumulative doses 7. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil hydroxychloroquine hyperpigmentation Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, Hydroxychloroquine-related skin discoloration CMAJ How long plaquenil after positive anaPlaquenil and vision problemsPlaquenil for sinflammatory oaChloroquine high creatininePlaquenil fatigue lupus Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Persistent cutaneous hyperpigmentation due to.. Will you have Skin hyperpigmentation with Plaquenil - eHealthMe. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. Oct 30, 2008 Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action.