She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Lysosomal swelling by chloroquine Plaquenil and cellcept Plaquenil dosage for older adults Hydroxychloroquine myositis Apr 30 2013 by Theodore Leng, MD, MS Fundus autofluorescence from a 44-year-old woman with bilateral plaquenil toxicity. There is an area of hyperautofluorescence that corresponds to areas of outer retinal damage. Sep 01, 2018 Over time, or with continued IV drug abuse, these deposits can lead to complications, such as retinal artery occlusion, neovascularization and vitreous hemorrhage, all of which can cause severe progressive vision loss. On SD-OCT, the crystalline deposits are observed as hyperreflective dots in the inner retina that distribute along the arteries. Patients suspected of developing retinal toxicity should discontinue chloroquine therapy if possible and undergo further evaluation to confirm toxicity. Take-home points. Patients started on chloroquine or hydroxychloroquine for systemic inflammation are at low but real risk of retinal toxicity from these medications. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal deposits plaquenil infared imaging Infrared imaging of sub-retinal structures in the human., Optometric Management - Retina What are similar drugs to plaquenilI stopped plaquenil and now i have goutChloroquine pronunciationPlaquenil and period changesPlaquenil sjogren& 39 Retinal imaging takes a digital picture of the back of your shows the retina where light and images hit, the optic disk a spot on the retina that holds the optic nerve, which sends. Retinal Imaging Purpose, Procedure, Risks, Resutls. Spotlight Case Chloroquine - The American Society of Retina.. Clinical applications of fundus autofluorescence in retinal.. Aug 06, 2014 Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Etinopathy were monitored for 6 months to 82 months after HCQ cessation with multimodal imaging including spectral domain optical coherence tomography and fundus autofluorescence imaging at 488 nm standard and 787 nm near-infrared autofluorescence. Tests of visual function including visual acuity, Humphrey visual field testing, and multifocal electroretinography mfERG were performed. Apr 01, 2014 Figure 9. Examples of patients with reticular pseudodrusen. Note the typical reticular pattern of infrared images center column and the focal deposits above the RPE. As a result, the term subretinal drusenoid deposits has been suggested to clarify the existing nomenclature.