Chloroquine in chikungunya

Discussion in 'Plaquenil' started by Insoffhes, 20-Mar-2020.

  1. umka XenForo Moderator

    Chloroquine in chikungunya


    Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

    Chloroquine used for lupus Deschloroquine used on chloroquine resistant parasites

    Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed i a prophylactic study in a non-human primate model NHP; and ii a curative study "CuraChik", which was performed during. To evaluate whether chloroquine CQ is more effective than meloxicam for treating early musculoskeletal pain and arthritis following acute chikungunya CHIK virus infection. Methods. During the 2006 CHIK epidemic, 509 rural community cases of acute CHIK virus infection were identified in the district of Sholapur in India. Nov 17, 2017 Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis. Quinolone-N-acylhydrazone hybrids as potent Zika and Chikungunya virus inhibitors Roberta K. F. Marra.

    Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus.

    Chloroquine in chikungunya

    Pharmacologic management of pain in patients with Chikungunya., Effectiveness of Chloroquine and Inflammatory Cytokine.

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  6. It is true that chloroquine displays antiviral and anti-inflammatory properties that, in our opinion, merit testing in the clinical management of some viral diseases. However, we reported no data on chikungunya, nor did we mention this disease in our articles in The Lancet Infectious Diseases.

    • On the use of chloroquine for chikungunya - The Lancet..
    • Repurposing of the anti-malaria drug chloroquine for Zika..
    • Treatment of Chikungunya.

    Chikungunya virus CHIKV is a mosquito-borne pathogen that has a major health impact in humans and causes acute febrile illness in humans accompanied by joint pains and, in many cases, persistent arthralgia lasting for weeks to years. CHIKV reemerged in 2005-2006 in several parts of the Indian Ocean islands and India after a gap of 32 years, causing millions of cases. The re-emergence of. In their Review on chikungunya, Gilles Pialoux and colleagues1 quote a Reflection and Reaction commentary previously published by our group2 as the source for the statement that “a clinical trial in South Africa failed to confirm the clinical efficacy of chloroquine on arthralgia”. It is true that chloroquine displays antiviral and anti-inflammatory properties that, in our opinion, merit. Sep 17, 2019 Where Has Chikungunya Virus Been Found? Prior to 2013, chikungunya virus cases and outbreaks had been identified in countries in Africa, Asia, Europe, and the Indian and Pacific Oceans. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories.

     
  7. CompDocs Well-Known Member

    400-600 mg (310-465 mg base) PO daily for 4-12 weeks; maintenance: 200-400 mg (155-310 mg base) PO daily With prolonged therapy, obtain CBCs periodically 400 mg (310 mg base) PO once or twice daily; maintenance: 200-400 mg (155-310 mg base) PO daily With prolonged therapy, obtain CBCs periodically 100-200 mg (77.5-155 mg base) PO 2-3 times/wk Take with food or milk Nausea, vomiting Headache Dizziness Irritability Muscle weakness Aplastic anemia Leukopenia Thrombocytopenia Corneal changes or deposits (visual disturbances, blurred vision, photophobia; reversible on discontinuance) Retinal damage with long-term use Bleaching of hair Alopecia Pruritus Skin and musculoskeletal pigmentation changes Weight loss, anorexia Cardiomyopathy (rare) Hemolysis (individuals with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency) Prolongs QT interval Ventricular arrhythmias and torsade de pointes Vertigo Tinnitus Nystagmus Nerve deafness Deafness Irreversible retinopathy with retinal pigmentation changes (bull’s eye appearance) Visual field defects (paracentral scotomas) Visual disturbances (visual acuity) Maculopathies (macular degeneration) Decreased dark adaptation Color vision abnormalities Corneal changes (edema and opacities) Abdominal pain Fatigue Liver function tests abnormal Hepatic failure acute Urticaria Angioedema Bronchospasm Decreased appetite Hypoglycemia Porphyria Weight decreased Sensorimotor disorder Skeletal muscle myopathy or neuromyopathy Headache Dizziness Seizure Ataxia Extrapyramidal disorders such as dystonia Dyskinesia Tremor Rash Pruritus Pigmentation disorders in skin and mucous membranes Hair color changes Alopecia Dermatitis bullous eruptions including erythema multiforme Stevens-Johnson syndrome Toxic epidermal necrolysis Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) Photosensitivity Dermatitis exfoliative Acute generalized exanthematous pustulosis (AGEP); AGEP has to be distinguished from psoriasis; hydroxychloroquine may precipitate attacks of psoriasis Pyrexia Hyperleukocytosis Hypersensitivity to 4-aminoquinoline derivatives Retinal or visual field changes due to 4-aminoquinoline compounds Long-term therapy in children Not effective against chloroquine-resistant strains of P. Individual plans may vary and formulary information changes. A Rare but Reversible Cause of Myopathy Hydroxychloroquine. Plaquenil and small fiber neuropathy - NeuroTalk Support. Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  8. freddo Moderator

    The NICE British National Formulary (BNF) sites is only available to users in the UK, Crown Dependencies and British Overseas Territories. Atovaquone-Proguanil - Side Effects, Dosage, Interactions. Chloroquine and/or Proguanil - Fit for Travel Chloroquine - Wikipedia
     
  9. Borbosso Moderator

    Hydroxychloroquine Price of 3 Brands / Trade Names Medindia Hydroxychloroquine - Price List of 3 Brands. Information about drug Hydroxychloroquine includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. To view the price of the drug, click on the brand name. The generic Hydroxychloroquine is manufactured by one company.

    Plaquenil / hydroxychloroquine shortage update an.
     
  10. wapai New Member

    Stopping plaquenil. DailyStrength I stopped taking the plaquenil the beginning of December. It doesn't agree with my stomach I take it with meals too. And since I hadn't had a miraculous recovery the 6 months I'd been on it, I didn't think there was any harm in stopping it. BUT after being off it for a month and a half my body feels like it's falling apart.

    Long-Term Side Effects of Plaquenil for Rheumatoid.