Hydroxychloroquine qt prolongation

Discussion in 'Plaquenil' started by Slayer, 26-Feb-2020.

  1. Rev Well-Known Member

    Hydroxychloroquine qt prolongation


    The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened.

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    Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. QT prolongation has occurred during therapeutic use of atomoxetine and following overdose. Drugs associated with QT Prolongation, QTc prolongation. LITFL Further Reading. ECG Library Basics – Waves, Intervals, Segments and Clinical Interpretation; ECG A to Z by diagnosis – ECG interpretation in clinical context Cardiac Effects, including Cardiomyopathy and QT prolongation Postmarketing cases of life-threatening and fatal cardiomyopathy have been reported with use of hydroxychloroquine sulfate as well as with use of chloroquine. Patients may present with atrioventricular block, pulmonary hypertension, sick sinus syndrome or with cardiac complications.

    The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used.

    Hydroxychloroquine qt prolongation

    Plaquenil - FDA prescribing information, side effects and uses, Drugs Causing QT Prolongation • LITFL Medical Blog • ECG Library Basics

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  6. Metabolism of a QT-prolonging drug or by causing an electrolyte disturbance that induces TdP Drugs to Avoid in Congenital Long QT. These drugs pose a high risk of TdP for patients with CLQTS and include all those in the above 3 categories PLUS additional drugs that do not prolong the QT but have a special risk because of their actions

    • Drugs and the QT Interval – What Do Pharmacists Need to Know?.
    • Hydroxychloroquine Tablets - FDA prescribing information..
    • Chronic hydroxychloroquine use associated with QT..

    QT Interval prolongation Hydroxychloroquine has the potential to prolong the QTc interval in patients with specific risk factors. Hydroxychloroquine should be used with caution in patients with congenital or documented acquired QT prolongation and/or known risk factors for prolongation of the QT internal such as • advanced age, Heart problems like heart failure and a certain abnormal heartbeat prolonged QT interval have happened with hydroxychloroquine. Sometimes, these heart problems have been deadly. Call your doctor right away if you have a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in. HS34-HS40. ABSTRACT QT prolongation is a rare adverse event associated with many drugs, including antipsychotics and antidepressants. The majority of cases have occurred in patients taking an offending agent with multiple identifiable risk factors for corrected QT QTc prolongation.

     
  7. technick User

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Side Effects - Hydroxychloroquine MedlinePlus Drug Information Hydroxychloroquine Side-effects, uses, time to work
     
  8. Gevak Guest

    Hydroxychloroquine Oral Uses, Side Effects, Interactions. For lupus or rheumatoid arthritis, take this medication by mouth, usually once or twice daily or as directed. Your doctor may gradually increase your dose. hydroxychloroquine 200 mg tablet.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  9. Fonari Guest

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