I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Maralone vs doxycycline vs chloroquine Chloroquine chemistry Re Plaquenil side effects Plaquenil made me a bit nauseated in the beginning but that wnet away within a few weeks. You usually need to be on Plaquenil for a few mon ths for it to take effect. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Side effects after stopping plaquenil Plaquenil and. diarrhea! rheumatoid, Taking Plaquenil for Rheumatoid Arthritis Plaquenil for discoid lupusSandoz plaquenil Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or; hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Common and Rare Side Effects for Plaquenil Oral. Stopping plaquenil. DailyStrength. In this review, we analyze Plaquenil side effects by the time on the drug, gender and age of the people who have side effects while taking Plaquenil. The review is based on 57,733 people who have side effects while taking the drug from Food and Drug Administration FDA. Like I have pressure on the top of my head. I nver had this before. Could this be a side effect of the Plaquenil and does it normaly go away after I take it for a while? Answer. That is an unusual side effect for Plaquenil. I would try stopping and restarting it to make sure Plaquenil is at fault. Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or.