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    Toxicology Question of the Week March 26, 2018 Does naloxone reverse clonidine toxicity? The issue of administering hi-dose naloxone to pediatric patients has caused more anxiety than you can imagine. I have had many calls from physicians when the Poison Center recommends administering 10 mg naloxone IVP to children. Pharmacists have refused to fill the order, nurses have refused to administer it, and I have even received a call from a Chief of Staff regarding our recommendations. We are trying to reverse released endorphins, which require the same amount of naloxone, no matter how big you are. Now we have demonstrated that hi-dose naloxone in clonidine toxicity is safe and that it works the majority of the time. Naloxone reverses toxicity because clonidine causes the release of beta-endorphin (in patients with higher sympathetic tone) and naloxone reverses the effects of the beta endorphin. Administering 2 mg five times is not the same as administering 10 mg IVP. AND, it doesn’t work as well in those with lower sympathetic tone (which we have no way of determining clinically). Clonidine Toxicity - Medscape inderal la Clonidine • Life in the Fast Lane • LITFL • Medical Blog Does naloxone reverse clonidine toxicity? - Vanderbilt.
     
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