MRI signal abnormalities in the disc have been described predominantly as low signal intensity on T2 weighted images. Loss of disc height and disc calcification are the most common spine imaging manifestations. Homogentisic acid and its metabolites are deposited in fibrous and connective tissues including the intervertebral disc leading to premature degeneration. D., Non ASSR Member Excerpta Extraordinaire Mentor Award: No Institution where work was conducted William Beaumont Hospital Affiliation and Department Diagnostic Radiology, William Beaumont Hospital 100 RO Address 3601 W. Royal Oak, Michigan 48073 Phone: 2488980648, Fax: 2488985490 Email: [email protected] Alkaptonuria (Ochronosis) is a rare metabolic disorder characterized by deficiency of homogentisic acid oxidase. Increased signal intensity on T1 weighted images in connective tissue elsewhere in the body has been described due to the paramagnetic effects of the deposited metabolites. We present a case of a 49 year old man who presented with acute radiculopathy superimposed on chronic back pain who did not have an established diagnosis of alkaptonuria. MRI demonstrated a hyperintense disc on T1 weighted images. The imaging findings and the nature of the disc led to a diagnostic evaluation that confirmed the diagnosis of alkaptonuria. xanax what is To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more VALACYCLOVIR (val ay SYE kloe veer) is an antiviral medicine. It is used to treat or prevent infections caused by certain kinds of viruses. Do not take your medicine more often than directed. Examples of these infections include herpes and shingles. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. 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