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Duloxetine Cymbalta ®; Eli Lilly and Co. is classified as a selective serotonin and. Venlafaxine ER 150mg Capsules Generic Effexor XR. Product Summary This product requires a valid prescription for shipment, please note that. Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. 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