The Repurposing Drugs in Oncology (Re DO) project, an international collaboration between the Anticancer Fund, Belgium, and US based Global Cures, says that existing and widely-used non-cancer drugs may represent a relatively untapped source of novel therapies for cancer. Historically, pharmaceutical companies devote little time to "repurposing" existing drugs. The Re DO project hopes to change that, raising awareness by publishing a series of articles in ecancer to share evidence for using these therapies in cancer medicine. Propranolol is the latest in a series of drugs that could offer cheap, safe and effective solutions to cancer. It's available globally in generic form and is on the WHO List of Essential Medicines -- particularly in angiosarcoma, a rare form of heart cancer. "The evidence to date in angiosarcoma is especially compelling," says study author Pan Pantziarka, Ph D, of the Anticancer Fund, Belgium. "Here is a rare disease with high unmet needs that is unlikely to attract investment from the commercial drug development sector. lasix pills Key clinical point: A single 40-mg dose of oral propranolol, judiciously timed, is a highly promising novel treatment for anxiety disorders. Major finding: The beta-blocker must be given within an hour before to an hour after therapist-facilitated reactivation of the fear memory. Study details: This study included 30 healthy volunteers who underwent a cued Pavlovian fear-conditioning program. Soeter’s study of the time- and sleep-dependent nature of propranolol-induced amnesia was supported by the Netherlands Organization for Scientific Research, where she is employed.– A single 40-mg dose of oral propranolol, judiciously timed, constitutes an outside-the-box yet highly promising treatment for anxiety disorders, and perhaps for posttraumatic stress disorder as well, Marieke Soeter, Ph D, said at the annual congress of the European College of Neuropsychopharmacology. The concept here is that the beta-blocker, when given with a brief therapist-led reactivation of a fear memory, blocks beta-adrenergic receptors in the brain so as to interfere with the specific proteins required for reconsolidation of that memory, thereby disrupting the reconsolidation process and neutralizing subsequent expression of that memory in its toxic form. In effect, timely administration of one dose of propranolol, a drug that readily crosses the blood/brain barrier, achieves pharmacologically induced amnesia regarding the learned fear, explained , a clinical psychologist at TNO, the Netherlands Organization for Scientific Research, an independent nonprofit translational research organization.“It looks like permanent fear erasure. You can never say that something is erased, but we have not been able to get it back,” she said. “Propranolol achieves selective erasure: It targets the emotional component, but knowledge is intact. Nolvadex hcg Viagra and testosterone Propranolol taken once daily at doses of 160, 240 and 320mg, was shown to be as effective as. One patient was withdrawn from the study after an ad-. viagra 25mg cost In a placebo-controlled study, propranolol given to medical students with test anxiety before an exam slightly improved their performance in verbal reasoning. Randomization will be to either propranolol or placebo. The 10-week study treatment period is divided into 1 week of drug titration, 8 weeks of. This lesson defines a cardiovascular medication known as propranolol. You'll learn how it works and, as a result, what it's used for. You'll also learn why propranolol might be effective in treating, of all things, anxiety. As you just learned, if epinephrine stimulates the beta receptors, then we can expect a faster heart rate and increased blood pressure. Have you ever been really stressed out at the doctor's office? It's because a hormone called epinephrine (adrenaline) stimulates receptors, called beta receptors. Thus, by blocking beta receptors, propranolol helps to reverse these changes or prevent them in the first place. If you have, do you recall what your blood pressure or heart rate was, roughly? Their stimulation increases the rate at which your heart beats and it increases your blood pressure as well. More specifically, it's stimulation of the beta-1 receptors that leads to a faster heart rate. Keep this in mind as we go over propranolol, namely its uses (especially for anxiety). So, the blockage of these guys with propranolol decreases heart rate. Stimulation of beta-1 receptors also causes the release of a compound called renin, whose actions cause a cascade of events to occur, ones that end up increasing a person's blood pressure. The actor Laurence Olivier described it as shattering. The pianist Vladimir Horowitz found it so disabling that he didn't perform for 12 years. dread speaking in front of an audience, a 2001Gallup poll found. Stage fright—also known as performance anxiety—strikes all kinds of people, including surgeons, athletes, students, pilots, and even public speakers. While many people feel apprehensive in such situations, those with performance anxiety suffer from an intense fear of humiliation, embarrassment, or scrutiny by others. A stressful event such as a music recital or speech sets off their body's "fight or flight" response, triggering symptoms such as heavy sweating, heart palpitations, trembling, blushing, dry mouth, gastrointestinal distress, and hyperventilation. The anxiety drives some to abandon successful careers or self-medicate with alcohol or drugs. But other people sometimes use beta-blockers, most commonly propranolol (Inderal and generic), as well as pindolol (Visken and generic); acebutolol (Sectral and generic); and atenolol (Tenormin and generic). The Food and Drug Administration approved beta-blockers for the treatment of high blood pressure, heart conditions, and certain types of tremors, and for the prevention of migraines and repeat heart attacks. 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